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While this review focuses on recent studies derived from animal models, clinical studies of the beneficial effects of butyrate on human kidneys have also been conducted in recent years

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When the concentration of L-arginine or BH4 is low, or BH4 becomes oxidized under conditions of oxidative stress, there is increased endothelial dysfunction because vasoconstriction increases and vasodilation decreases, contributing to increased pressure within the vessels (91)